Multiple Sclerosis (MS)

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Multiple Sclerosis (MS)

Postby Admin on Wed May 20, 2009 3:06 pm

A chronic degenerative disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord (or both), which interferes with the nerve pathways, causing muscular weakness, loss of coordination and speech, and visual disturbances. It occurs chiefly in young adults and is thought to be a defect in the immune system that may be of genetic or viral origin.

Multiple Sclerosis

Multiple sclerosis (MS) is a neurological condition that affects the transfer of messages from the central nervous system to the rest of the body. As there's no cure, medical treatment concentrates on symptom relief.

What causes it?

Doctors believe it's caused by a combination of genetic and environmental factors. Although MS isn't primarily regarded as an inherited disorder, twin studies strongly suggest the presence of certain genes can make an individual susceptible to it. But other factors, possibly a viral infection, also play a part. There are no prenatal tests available. People with the condition experience recurrent episodes of inflammation and destruction of the sheaths that surround and protect nerves (known as dymyelination). Small plaques form throughout the central nervous system.

Research into MS around the world has shown that it is more likely to occur in countries that are far from the equator. For example, MS is relatively common in the UK, North America and Scandinavia, but hardly ever occurs in countries such as Malaysia and Ecuador. The reason for this is not fully understood, but it is thought that MS could be triggered by a particular bacteria or virus which thrives in a cooler environment.

What are the symptoms?

MS has a wide range of symptoms, is unpredictable and affects everyone differently. There are several different types, with different patterns of disease. One in five people affected has a benign form with mild attacks and no permanent disability, while another 15 per cent have a progressive disease that steadily worsens.

Symptoms vary depending on the type of MS, but typically come and go. The condition can affect any part of the body but usually starts with a single episode of nerve dysfunction, classically inflammation of the optic nerve in one eye. Other common symptoms include:

* Double or blurred vision
* Numbness or tingling in any part of the body
* Tiredness
* Temporary blindness
* Fatigue and dizziness
* Distortion or loss of sense of touch
* Limb weakness, spasticity and pain
* Incontinence
* Constipation
* Cognitive impairment

In 25% of cases of MS, the first symptom is inflammation (swelling) of the optic nerve, known as optic neuritis. This usually only affects one eye, and causes pain behind your eyeball and some loss of vision. You may also experience double vision, pain in both eyes, some colour blindness, and difficulty focusing (known as nystagmus).

If you have MS, you may find that extreme tiredness (fatigue) is your main symptom. You may find that fatigue worsens your other symptoms, such as problems with balance, vision and concentration. Cognitive problems refer to problems with mental processes such as thinking and learning. You may have trouble remembering and learning new things, problems with attention and concentration, slowed or confused speech, and reduced mental speed.

What's the treatment?

As its precise cause remains unclear, it's not possible to prevent the condition and there's no cure. Treatments include medication to relieve pain and spasms, physiotherapy, occupational therapy, steroids and beta-interferon. Complementary therapies used include acupuncture, massage and yoga. Cannabis is being researched as a possible treatment for pain and muscle spasticity in MS. Disease-modifying drugs may slow its progression.

As MS is such a varied and unpredictable condition, each person who has MS will need a different level of medical care and treatment. Once you have been diagnosed with MS, you should have a thorough assessment involving specialist nurses, physiotherapists, occupational therapists, speech and language therapists and social workers, who make up a specialist neurological rehabilitation team.

Depending on the amount of care you need, you will receive treatment from one, several or all the members of your local neurological rehabilitation team. They can also help you learn to care and treat yourself as much as possible.

Treatment to slow the progression of MS

MS cannot be cured but there are treatments that can reduce the number and severity of relapses. They may also help to slow the progression of the condition, although research into their long-term effects is limited.

Disease-modifying medicines

These treatments are injected into your muscle or under your skin, and they can only be prescribed by a neurologist who is part of a specialist neurological rehabilitation team. Your MS nurse can help you with the injections until you feel ready to carry them out yourself. Disease-modifying medicines work by reducing the amount of damage and scarring to the myelin in your central nervous system, which causes MS relapses.

Beta interferons (Avonex, Betaferon and Rebif):

Avonex is injected once a week into your muscle, Betaferon is injected under your skin every other day, and Rebif is injected under your skin three times a week. Beta interferons can all cause mild side effects, such as flu-like symptoms (headaches, chills, mild fever) for 48 hours after they are injected.

Glatiramer acetate (Copaxone):

Copaxone is injected under the skin every day. It does not usually cause any noticeable side effects, although in rare cases, it may cause tightness in your chest. Copaxone is only licensed to be used by people who have relapsing remitting MS (RRMS).

Linoleic acid:
Linoleic acid is an essential fatty acid, which is found naturally in several foods. There is some medical evidence that suggests that a diet rich in linoleic acid may help to reduce the duration and severity of MS relapses, and slow the progression of MS.

Tysabri is a monoclonal antibody that affects the actions of the body's immune system. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Tysabri is used to treat relapsing forms of multiple sclerosis. Tysabri, known generically as natalizumab, is designed to suppress the immune system which mistakenly attacks nerves in MS patients.Tysabri is given as an injection through a needle placed into a vein.Tysabri is also used to treat moderate to severe Crohn's disease in adults. It is usually given after other Crohn's disease medications have been tried without successful treatment of this condition.

Damaged Myelin in Multiple Sclerosis

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Re: Multiple Sclerosis (MS) Help and Information

Postby Alexandra Ames on Tue Sep 08, 2009 3:10 am

This is fantastic information, thank you. I am curious why one of the newer treatment options, Tysabri, is not discussed in this posting.

Also, is there a place where those diagnosed, or suspected, with MS can go to ask questions, share concerns and triumphs, etc. I am very interested in this type of forum.

Just FYI, I have been officially diagnosed with MS for 9 years, have used a variety of treatments at different times (Avonex, Beta Seron, LDN) and currently receive Tysabri infusions. I have SPMS and am completely functional, work full-time, write professionally, and raise teenagers.

With so much uncertainty and mis-information circulating (and many times, dispair) I wish to inspire hope. I would love feedback on the presence of such a forum. Thank you so much!

Alexandra Ames
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Re: Multiple Sclerosis (MS) Help and Information

Postby Admin on Thu Sep 10, 2009 4:34 am

Thanks for the feedback Alexandra, we have just added the new treatment option Tysabri into the MS information section. We would encourage our members to add any other additional information to the forum sections that you think would benefit our community.

The place to ask questions, share concerns and triumphs are in the Advice & Support section. We would greatly appreciate it if you can share your story with us in the introductions section and let us know how the Tysabri treatment is working for you.

Also if you have any suggestions for us, then please let us know as this is YOUR community and we will do everything we can to make your experience here at AbleSea as accessible as ever. If you want to see new features, new forum sections new developments then please let us know and we will provide it for you.

Thank you for the interest in the forum and we hope you will be an active participant in our lovely community and we are all here to help and support each other whilst offering advice and solutions to our members.
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Re: Multiple Sclerosis (MS)

Postby Holly_RS on Tue Nov 24, 2009 6:35 pm

This story has been making huge headlines in Canada as of late; has it been discussed anywhere else?
"Nobody can do everything, but everyone can do something." ~Author Unknown
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,which made him very proud .Traveling photographer discovered that Liu Bolin had almost invisible ,immediately let him in the &ldquo ;&rdquo nest ;former adjust posture ,to design the best angle ,the photographer press the shutter ,photographs have appeared on the magical scene :Liu Bolin has almost become a transparent body .
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In London, he disappeared in the &ldquo ;&rdquo ;&ldquo &rdquo phone booth master ;invisibility ;later, Liu Bolin rise to fame ,was &ldquo ;China Invisible Man &rdquo ;.Go abroad for exhibitions of his work ,he was still in London ,Paris ,Venice and other city play away ,[url=]abercrombie france[/url].
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Studies the life in Ji for many years ,Liu Bolin also think if in Ji &ldquo &rdquo ;stealth ,he will choose which place .Last year, Liu Bolin went to Ji attend the celebration ,a group of friends urged him to play again disappeared .
&ldquo ;when I refused, I must pick out a meaningful elements can stealth .&rdquo ;Liu Bolin said ,his home on the edge of the Yellow River, the Yellow River is China ,if in Ji &ldquo ;stealth &rdquo ;then ,he may have to the Bank of the river before ,&ldquo ;himself became a part of the Yellow River &rdquo ;.
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The powerful Meqdad family is seeking to put pressure on rebels to release clan member Hassan Al-Meqdad, who has been held by the Free Syrian Army (FSA) for two days.
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